Suven Life Sciences offers wide range of services for evaluating medications intended for various central nervous system disorders.
Animal models of cognition
- Object recognition task – Delay or scopolamine induced deficits
- Water maze – Scopolamine induced deficits
- Radial arm maze
- Social recognition task
- Contextual fear conditioning
- Cerebral blood flow
Animal models of psychosis
- Prepulse inhibition
- MK-801 or Amphetamine antagonism
- Conditioned avoidance
- Dominant submissive assay
- Resident intruder task
Animal models of anxiety
- Elevated plus maze
- Hole board
- Vogel conflict
- Novelty induced hypophagia
Animal models of depression
- Forced swim / Tail suspension test
- Dominant submissive assay
- Differential reinforcement at low rates-72s
Animal models of pain
- Acetic acid induced writhing/ Formalin induced nociception/ Hot plate
- Complete Freund’s adjuvant / Chemotherapy / Streptozotocin/ Capsaicin / Mono iodoacetate / Reserpine induced pain
- Spinal nerve ligation / Chronic constriction injury/ Partial sciatic nerve ligation
- Medial meniscal tear
- Chronic post-ischemia pain
- Spontaneous burrowing behavior
- In vivo electrophysiology
Other models
- MPTP induced Parkinson’s disease
- Erectile dysfunction
In Vivo Receptor Occupancy Assays
Suven offers tracer development and target engagement services using hot /cold tracers in selection of better clinical candidate and projecting clinical doses.
- Adenosine: A2A
- Nicotinic acetylcholine receptors: α4β2 and α7
- Cannabinoid CB1
- Dopamine D1 & D2
- GABAA
- Histamine: H3
- Serotonin: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT6, and 5-HT2C
- Phosphodiesterase 10
- Serotonin transporter (SERT)/Dopamine transporter (DAT)/Norepinephrine transporter (NET)
- Sigma-1
- Monoamine oxidase-A and B
- Novel tracers for non-validated targets
- In Vivo Receptor Occupancy AssaysView PDF
Microdialysis, Neurochemistry and Biomarker
Suven provides in vivo microdialysis and neurochemistry services to study the mechanism of action, efficacy and side-effect profile of centrally-acting drugs.
- Acetylcholine
- Histamine
- Glutamate, GABA and Glycine
- Dopamine, Norepinephrine, Serotonin, and its metabolites
- Peptides (Substance-P and PGE2)
- Beta amyloid (1-40, 1-42), Soluble APPa
- Corticosterone
- Interleukins
- Inositol 1- phosphate
- Prolactin
- Prostaglandin E2
- Substance P
- tele- methylhistamine
- Microdialysis, Neurochemistry and BiomarkerView PDF
Electroencephalography (EEG)
Suven has large spectrum of EEG assays with most advanced infrastructure using implantable telemetry (DSI, USA) to support early stage of drug discovery.
- Sleep/ wake activity
- Temperature and wake promoting activity
- Total EEG power
- Power analysis in frequency bands
- Assessment for seizure evaluation potential
- Assessment of cognitive biomarkers (Theta and Gamma Activity)
- Simultaneous power analysis in animal performing behavioral task
- Orexin-SAP induced chemical lesion model for narcolepsy
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