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In-vitro Screening and Molecular Biology
Suven Life Sciences have developed fully characterized and validated screening assays for targets like GPCR, transporters, Nuclear Receptors and Ligand gated ion channels.
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Click here Drug Metabolism and Pharmacokinetics
Suven
Life Sciences is dedicated to provide quality PK/TK/ADME
services to assist pharmaceutical and biotechnology
companies in preclinical development and candidate
selection. We have established various (all
species, hepatocellular, microsomal, supersomal, plasma,
etc) and (Rodent - mice, rat, rabbit, guinea pig
& Non Rodent - Beagle dogs) pharmacokinetics and
metabolism assays.
Pharmacokinetic Assays
- Single Dose PK
- Bioavailability
- Intravenous Cassette dose
- Brain Penetration Study
- Reactive Metabolite Identification
- CSF Pharmacokinetic Study
- Free Drug Estimation in brain dialysate fluids (Microdialysis)
- Bioanalytical Method Development and Partial Validation.
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ADME
- Solubility of Test Item at pH 7.4
- Metabolic Stability
- Metabolite Identification
- CYP Inhibition
- Protein Binding
- Brain in Beaker
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Pharmacology
Suven Life Sciences has established various safety and efficacy pharmacology (CNS: Cognition, Depression, Anxiety; Obesity) models to screen and/or develop lead compounds. We utilize our scientific expertise to validate new drug targets or to develop novel models for assessing client-specific targeting needs.
Safety Pharmacology
- General Safety Assays
- CNS Safety Assays
- GI Safety Assays
- Respiratory Safety Assays
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CNS Pharmacology
(Cognition, Depression and Pain) (Click
here)
- Addiction Assay
- Anxiety Assays
- Cognition Assays
- Depression Assays
- Schizophrenia Assays
- General Behavioral Assays
- Brain Microdialysis Assays (Click here)
- Receptor Occupancy Studies
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Toxicology and Genotoxicity Suven Life Sciences is offering exploratory and discovery rodent (mice and rat) toxicity evaluations (4, 7, 14 and 28 day), including histopathology/review & clinical chemistry and
AMES assays to assist pharmaceutical and biotechnology companies in preclinical development and candidate selection.
Discovery Tox Express:
(Click here)
wherein Tox studies will be conducted on your newchemical entities in the early stage of discovery. The
Tox
data would be generated in extremely rapid timelines atthe same time with highest quality and scientific
integrityfor your decision making of molecule progression.
- Acute Toxicity Studies in rodents
- Maximum tolerated dose (MTD) studies in rodents
- 4 / 7 / 14 / 28 day repeat dose toxicity studies in rodents
- In-vivo & In-vitro Genotoxicity Studies
- Toxicokinetic Studies in rodents
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Bioanalysis Suven Life Sciences offers a seamless process for your pharmacokinetic and toxicokinetic evaluations, one that begins with formulation and dosing, followed by sample collection and bioanalytical mehod development, validation and ending with data analysis and report generation. Quantitation of your compound in biological matrices such as blood, plasma, serum, urine, and tissues is usually accomplished using LC-MS/MS. Access to scientific expertise and technical support for data interpretation. All bioanalytical services are conducted according relevant regulatory guidelines.
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